BDBM543502 US11279703, TABLE 4.3::US11279703, TABLE 6.321

SMILES CN1CCN(CC1)c1ccc(Nc2ncc3ccn(-c4ccc5N(CCc5c4)S(=O)(=O)C(C)(C)C)c3n2)cc1

InChI Key InChIKey=ZUJYNRUPFNMNQS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 543502   

TargetTyrosine-protein kinase JAK2(Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543502(US11279703, TABLE 4.3 | US11279703, TABLE 6.321)
Affinity DataIC50: 0.600nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543502(US11279703, TABLE 4.3 | US11279703, TABLE 6.321)
Affinity DataIC50: 0.600nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543502(US11279703, TABLE 4.3 | US11279703, TABLE 6.321)
Affinity DataIC50: 1.00E+4nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent