BDBM543578 US11279703, TABLE 6.167::US11279703, TABLE 6.172

SMILES Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(NS(=O)(=O)C(C)(C)C)c1

InChI Key InChIKey=NIFODZUHQBXOII-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 543578   

TargetTyrosine-protein kinase JAK2(Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543578(US11279703, TABLE 6.167 | US11279703, TABLE 6.172)
Affinity DataIC50: 2.30nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543578(US11279703, TABLE 6.167 | US11279703, TABLE 6.172)
Affinity DataIC50: 2.30nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543578(US11279703, TABLE 6.167 | US11279703, TABLE 6.172)
Affinity DataIC50: 185nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543578(US11279703, TABLE 6.167 | US11279703, TABLE 6.172)
Affinity DataIC50: 420nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543578(US11279703, TABLE 6.167 | US11279703, TABLE 6.172)
Affinity DataIC50: 420nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4 [342-460](Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543578(US11279703, TABLE 6.167 | US11279703, TABLE 6.172)
Affinity DataIC50: 451nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetBromodomain testis-specific protein [22-138](Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543578(US11279703, TABLE 6.167 | US11279703, TABLE 6.172)
Affinity DataIC50: 638nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetBromodomain-containing protein 2 [91-163](Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543578(US11279703, TABLE 6.167 | US11279703, TABLE 6.172)
Affinity DataIC50: 682nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

TargetBromodomain-containing protein 3 [51-123](Human)
Aptose Biosciences

US Patent
LigandPNGBDBM543578(US11279703, TABLE 6.167 | US11279703, TABLE 6.172)
Affinity DataIC50: 853nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent