BDBM543843 2-(((2S,4s,6S)-6-((4-(4- methoxyphenyl)thiazol- 2-yl)amino)spiro[3.3] heptan-2- yl)oxy)nicotinamide::US11299488, Example 8

SMILES COc1ccc(cc1)-c1csc(N[C@H]2C[C@]3(C2)C[C@@H](C3)Oc2ncccc2C(N)=O)n1

InChI Key InChIKey=LTFWVGIQFOGBCN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 543843   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM543843(2-(((2S,4s,6S)-6-((4-(4- methoxyphenyl)thiazol- 2-...)
Affinity DataIC50: 115nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2022
Entry Details
US Patent