BDBM543975 US11279719, Example I-7

SMILES OP(O)(=O)C(Nc1nc(nc2sccc12)-c1cccc(NC(=O)Nc2ccc(F)cc2)c1)P(O)(O)=O

InChI Key InChIKey=ADZFVWRKYSFEGP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 543975   

TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM543975(US11279719, Example I-7)
Affinity DataIC50:  41nMAssay Description:Inhibition of recombinant human N- terminal His-tagged /TEV cleavage site fused GGPPS (1 to 300 residues) expressed in Escherichia coli BL21 (DE3) us...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM543975(US11279719, Example I-7)
Affinity DataIC50: <100nMAssay Description:The assay was based on a literature procedure (Kavanagh, et al. J. Biol. Chem., 2006, 281, 22004-22012) with minor modifications. All assays were run...More data for this Ligand-Target Pair
In DepthDetails US Patent