BDBM544052 (M)-6-Chloro- 4-[(2S,5R)-2,5- dimethyl-4- prop-2-enoyl- piperazin-1-yl]- 7-(2,5- dimethyl-3- thienyl)-1-(2- isopropyl-4- methyl-3- pyridyl)pyrido [2,3- d]pyrimidin-2- one::US11285156, Ex.# 92-7

SMILES CC(C)c1nccc(C)c1-n1c2nc(-c3cc(C)sc3C)c(Cl)cc2c(nc1=O)N1C[C@@H](C)N(C[C@@H]1C)C(=O)C=C

InChI Key InChIKey=VHJHIBOMZVGXRQ-MOPGFXCFSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 544052   

TargetGTPase KRas [1-169,G12C,C118A](Human)
Amgen

US Patent
LigandPNGBDBM544052((M)-6-Chloro- 4-[(2S,5R)-2,5- dimethyl-4- prop-2-e...)
Affinity DataIC50:  31nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent