BDBM544171 6-Chloro-1-(4-chloro- 6-isopropyl-pyrimidin- 5-yl)-4-[(2S,5R)-2,5- dimethyl-4-prop-2- enoyl-piperazin-1-yl]- 7-(2- fluorophenyl)pyrido [2,3-d]pyrimidin-2-one::US11285156, Ex.# 102-5-1::US11285156, Ex.# 102-5-2
SMILES CC(C)c1ncnc(Cl)c1-n1c2nc(c(Cl)cc2c(nc1=O)N1C[C@@H](C)N(C[C@@H]1C)C(=O)C=C)-c1ccccc1F
InChI Key InChIKey=MKRCJCLMWFISCS-SJORKVTESA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 544171
Affinity DataIC50: 173nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair