BDBM544171 6-Chloro-1-(4-chloro- 6-isopropyl-pyrimidin- 5-yl)-4-[(2S,5R)-2,5- dimethyl-4-prop-2- enoyl-piperazin-1-yl]- 7-(2- fluorophenyl)pyrido [2,3-d]pyrimidin-2-one::US11285156, Ex.# 102-5-1::US11285156, Ex.# 102-5-2

SMILES CC(C)c1ncnc(Cl)c1-n1c2nc(c(Cl)cc2c(nc1=O)N1C[C@@H](C)N(C[C@@H]1C)C(=O)C=C)-c1ccccc1F

InChI Key InChIKey=MKRCJCLMWFISCS-SJORKVTESA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 544171   

TargetGTPase KRas [1-169,G12C,C118A](Human)
Amgen

US Patent
LigandPNGBDBM544171(6-Chloro-1-(4-chloro- 6-isopropyl-pyrimidin- 5-yl)...)
Affinity DataIC50:  173nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGTPase KRas [1-169,G12C,C118A](Human)
Amgen

US Patent
LigandPNGBDBM544171(6-Chloro-1-(4-chloro- 6-isopropyl-pyrimidin- 5-yl)...)
Affinity DataIC50:  31nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent