BDBM544216 6-Chloro-1-(4- cyclopropyl-6- isopropyl-pyrimidin-5- yl)-4-[(2S,5R)-2,5- dimethyl-4-prop-2- enoyl-piperazin-1-yl]- 7-(o-tolyl)pyrido[2,3- d]pyrimidin-2-one::US11285156, Ex.# 108-2-1::US11285156, Ex.# 108-2-2
SMILES CC(C)c1ncnc(C2CC2)c1-n1c2nc(c(Cl)cc2c(nc1=O)N1C[C@@H](C)N(C[C@@H]1C)C(=O)C=C)-c1ccccc1C
InChI Key InChIKey=BQUVBVIWRDEFMA-RTWAWAEBSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 544216
Affinity DataIC50: 181nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Affinity DataIC50: 35nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair