BDBM544252 6-Chloro-1-(2,4- diisopropyl-3- pyridyl)-4-[(2S,5R)- 2,5-dimethyl-4-prop- 2-enoyl-piperazin-1- yl]-7-(2- isopropylphenyl) pyrido [2,3-d]pyrimidin- 2-one::US11285156, Ex.# 124-8
SMILES CC(C)c1ccccc1-c1nc2n(-c3c(ccnc3C(C)C)C(C)C)c(=O)nc(N3C[C@@H](C)N(C[C@@H]3C)C(=O)C=C)c2cc1Cl
InChI Key InChIKey=VCGXNKGCAABXDM-RPWUZVMVSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 544252
Affinity DataIC50: 34nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair