BDBM544252 6-Chloro-1-(2,4- diisopropyl-3- pyridyl)-4-[(2S,5R)- 2,5-dimethyl-4-prop- 2-enoyl-piperazin-1- yl]-7-(2- isopropylphenyl) pyrido [2,3-d]pyrimidin- 2-one::US11285156, Ex.# 124-8

SMILES CC(C)c1ccccc1-c1nc2n(-c3c(ccnc3C(C)C)C(C)C)c(=O)nc(N3C[C@@H](C)N(C[C@@H]3C)C(=O)C=C)c2cc1Cl

InChI Key InChIKey=VCGXNKGCAABXDM-RPWUZVMVSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 544252   

TargetGTPase KRas [1-169,G12C,C118A](Human)
Amgen

US Patent
LigandPNGBDBM544252(6-Chloro-1-(2,4- diisopropyl-3- pyridyl)-4-[(2S,5R...)
Affinity DataIC50:  34nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent