BDBM544386 4-((2S,5R)-4-Acryloyl-2,5-dimethylpiperazin-1-yl)-6-chloro-1-(2-fluoro-4isopropyl-6-methylpyrimidin-5-yl)-7-(2-fluorophenyl)pyrido[2,3-d]pyrimidin-2(1H)-one, Single Isomer::US11285156, Ex.# 200

SMILES CC(C)c1nc(F)nc(C)c1-n1c2nc(c(Cl)cc2c(nc1=O)N1C[C@@H](C)N(C[C@@H]1C)C(=O)C=C)-c1ccccc1F

InChI Key InChIKey=ZZQPPUIDFWDUNX-SJORKVTESA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 544386   

TargetGTPase KRas [1-169,G12C,C118A](Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM544386(4-((2S,5R)-4-Acryloyl-2,5-dimethylpiperazin-1-yl)-...)
Affinity DataIC50:  30nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent