BDBM547567 US11292791, Example 840::US20240016795, Compound 4

SMILES COC(=O)[C@@H]1CCC[C@H](C1)n1c(Cc2ccccc2)nc2c3CC[C@H](C)N(C(=O)OC)c3ccc12

InChI Key InChIKey=HOFKIGVLMHUPPX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 547567   

TargetCREB-binding protein(Human)
Forma Therapeutics

US Patent
LigandPNGBDBM547567(US11292791, Example 840 | US20240016795, Compound ...)
Affinity DataIC50: 10nMAssay Description:The potency and selectivity of CBP/P300 inhibitor compounds including Compound 1 were determined in biochemical time resolved fluorescence assays usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2024
Entry Details
US Patent

TargetHistone acetyltransferase p300(Human)
Forma Therapeutics

US Patent
LigandPNGBDBM547567(US11292791, Example 840 | US20240016795, Compound ...)
Affinity DataIC50: 10nMAssay Description:The potency and selectivity of CBP/P300 inhibitor compounds including Compound 1 were determined in biochemical time resolved fluorescence assays usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2024
Entry Details
US Patent

TargetCREB-binding protein(Human)
Forma Therapeutics

US Patent
LigandPNGBDBM547567(US11292791, Example 840 | US20240016795, Compound ...)
Affinity DataIC50: 55nMAssay Description:The assay was performed in a final volume of 6 μL in assay buffer containing 50 mM Hepes (pH 7.5, (0.5M Hepes, pH 7.5 solution; Teknova H1575)),...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4(Human)
Forma Therapeutics

US Patent
LigandPNGBDBM547567(US11292791, Example 840 | US20240016795, Compound ...)
Affinity DataIC50: 5.05E+4nMAssay Description:The assay was performed in a final volume of 6 μL in assay buffer containing 50 mM Hepes (pH 7.5, (0.5M Hepes, pH 7.5 solution; Teknova H1575)),...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
US Patent