BDBM547889 WO2022090481, Example I-108
SMILES COc1ccncc1-c1cc2n(ncc2c(C)n1)-c1cc2n(C)c(C(=O)N3C[C@H](C)N[C@H](C)C3)c(C)c2c(n1)C(C)C
InChI Key InChIKey=MDTMLEFFFZVDMM-KDURUIRLSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 547889
TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Human)
Boehringer Ingelheim International
WIPO
Boehringer Ingelheim International
WIPO
Affinity DataIC50: 1.70nMAssay Description: Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ...More data for this Ligand-Target Pair