BDBM549027 2-(((2S,4s,6S)-6-((4- fluoro-1-methyl-1H- benzo[d]imidazol-2- yl)amino)spiro[3.3] heptan-2-yl) oxy)nicotinamide::US11299488, Example 14

SMILES Cn1c(N[C@H]2C[C@]3(C2)C[C@@H](C3)Oc2ncccc2C(N)=O)nc2c(F)cccc12

InChI Key InChIKey=ZMBCKCSUNPOILK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 549027   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM549027(2-(((2S,4s,6S)-6-((4- fluoro-1-methyl-1H- benzo[d]...)
Affinity DataIC50: 320nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2022
Entry Details
US Patent