BDBM549046 US11299480, Example 102

SMILES Fc1c(F)c(F)c(c(F)c1F)S(=O)(=O)N1CC[C@@H]1C(=O)N(Cc1ccc(cn1)C1CCCCC1)c1ccc2c(cn[nH]c2=O)c1

InChI Key InChIKey=VPZCOFCROGWLOY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 549046   

TargetSignal transducer and activator of transcription 3(Human)
Cedars-Sinai Medical Center

Curated by ChEMBL
LigandPNGBDBM549046(US11299480, Example 102)
Affinity DataIC50: 380nMAssay Description:Inhibition of C-terminal 6His-tagged recombinant human STAT3 (127 to 711 residues) DNA-binding activity transfected in v-Src transformed mouse NIH3T3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Cedars-Sinai Medical Center

Curated by ChEMBL
LigandPNGBDBM549046(US11299480, Example 102)
Affinity DataIC50: 660nMAssay Description:Inhibition of C-terminal 6His-tagged recombinant human STAT3 (127 to 711 residues) DNA-binding activity transfected in v-Src transformed mouse NIH3T3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Cedars-Sinai Medical Center

Curated by ChEMBL
LigandPNGBDBM549046(US11299480, Example 102)
Affinity DataIC50: 663nMAssay Description:Nuclear extract preparations and DNA-binding activity/electrophoretic mobility shift assay (EMSA) were carried out as previously described (Zhang X, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2022
Entry Details
US Patent

TargetSignal transducer and activator of transcription 3(Human)
Cedars-Sinai Medical Center

Curated by ChEMBL
LigandPNGBDBM549046(US11299480, Example 102)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of C-terminal 6His-tagged recombinant human STAT3 (127 to 711 residues) DNA-binding activity transfected in v-Src transformed mouse NIH3T3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Cedars-Sinai Medical Center

Curated by ChEMBL
LigandPNGBDBM549046(US11299480, Example 102)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of recombinant wild type tyrosine phosphorylated C-terminal 6His tagged human STAT3 (127 to 711 residues) DNA-binding activity transfected...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Cedars-Sinai Medical Center

Curated by ChEMBL
LigandPNGBDBM549046(US11299480, Example 102)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of recombinant wild type tyrosine phosphorylated C-terminal 6His tagged human STAT3 C542S mutant (127 to 711 residues) DNA-binding activit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Cedars-Sinai Medical Center

Curated by ChEMBL
LigandPNGBDBM549046(US11299480, Example 102)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of recombinant wild type tyrosine phosphorylated C-terminal 6His tagged human STAT3 C426A mutant (127 to 711 residues) DNA-binding activit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Cedars-Sinai Medical Center

Curated by ChEMBL
LigandPNGBDBM549046(US11299480, Example 102)
Affinity DataIC50: 8.80E+3nMAssay Description:Inhibition of recombinant wild type tyrosine phosphorylated C-terminal 6His tagged human STAT3 C328A mutant (127 to 711 residues) DNA-binding activit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Cedars-Sinai Medical Center

Curated by ChEMBL
LigandPNGBDBM549046(US11299480, Example 102)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of recombinant wild type tyrosine phosphorylated C-terminal 6His tagged human STAT3 C468A mutant (127 to 711 residues) DNA-binding activit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Cedars-Sinai Medical Center

Curated by ChEMBL
LigandPNGBDBM549046(US11299480, Example 102)
Affinity DataIC50: 6.00E+5nMAssay Description:Displacement of 5-carboxyfluorescein GpYLPQTV-NH2 probe from C-terminal 6His-tagged recombinant human STAT3 (127 to 711 residues) SH2 domain extracte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Cedars-Sinai Medical Center

Curated by ChEMBL
LigandPNGBDBM549046(US11299480, Example 102)
Affinity DataIC50: 6.00E+5nMAssay Description:Displacement of 5-carboxyfluorescein GpYLPQTV-NH2 probe from C-terminal 6His-tagged recombinant human STAT3 (127 to 711 residues) SH2 domain extracte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Cedars-Sinai Medical Center

Curated by ChEMBL
LigandPNGBDBM549046(US11299480, Example 102)
Affinity DataIC50: 6.00E+5nMAssay Description:Displacement of 5-carboxyfluorescein GpYLPQTV-NH2 probe from C-terminal 6His-tagged recombinant human STAT3 (127 to 711 residues) SH2 domain extracte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed