BDBM549062 2-(((2S,4s,6S)-6-((6-fluoroquinoxalin-2-yl)amino)spiro[3.3]heptan-2-yl)oxy)nicotinamide::US11299488, Example 21

SMILES NC(=O)c1cccnc1OC1CC2(CC(C2)Nc2cnc3cc(F)ccc3n2)C1

InChI Key InChIKey=WYNDMQAAGMVPDY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 549062   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM549062( 2-(((2S,4s,6S)-6-((6-fluoroquinoxalin-2-yl)amino)...)
Affinity DataIC50: 73nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2022
Entry Details
US Patent