BDBM549118 BDBM50556884::US11299480, Example 53

SMILES OC(=O)c1ccc(cc1O)N(Cc1ccc(cn1)C1CCCCC1)C(=O)[C@H]1CCN1S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F

InChI Key InChIKey=PRLVPYXUDLHWQA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 549118   

LigandPNGBDBM549118(BDBM50556884 | US11299480, Example 53)
Affinity DataIC50: 270nMAssay Description:Inhibition of C-terminal 6His-tagged recombinant human STAT3 (127 to 711 residues) DNA-binding activity transfected in v-Src transformed mouse NIH3T3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM549118(BDBM50556884 | US11299480, Example 53)
Affinity DataIC50: 350nMAssay Description:Inhibition of C-terminal 6His-tagged recombinant human STAT3 (127 to 711 residues) DNA-binding activity transfected in v-Src transformed mouse NIH3T3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetSignal transducer and activator of transcription 3(Mouse)
University of Hawaii Cancer Center

Curated by ChEMBL
LigandPNGBDBM549118(BDBM50556884 | US11299480, Example 53)
Affinity DataIC50: 380nMAssay Description:Inhibition of oligonucleotide [32P]-labelled 5'-AGCITCATTTCCCGTAAATCCCTA probe binding to STAT3 SH2 domain in mouse NIH3T3/v-Src nuclear extract prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM549118(BDBM50556884 | US11299480, Example 53)
Affinity DataIC50: 384nMAssay Description:Nuclear extract preparations and DNA-binding activity/electrophoretic mobility shift assay (EMSA) were carried out as previously described (Zhang X, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2022
Entry Details
US Patent

LigandPNGBDBM549118(BDBM50556884 | US11299480, Example 53)
Affinity DataIC50: 600nMAssay Description:Inhibition of recombinant wild type tyrosine phosphorylated C-terminal 6His tagged human STAT3 (127 to 711 residues) DNA-binding activity transfected...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM549118(BDBM50556884 | US11299480, Example 53)
Affinity DataIC50: 664nMAssay Description:Nuclear extract preparations and DNA-binding activity/electrophoretic mobility shift assay (EMSA) were carried out as previously described (Zhang X, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2022
Entry Details
US Patent

LigandPNGBDBM549118(BDBM50556884 | US11299480, Example 53)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of C-terminal 6His-tagged recombinant human STAT3 (127 to 711 residues) DNA-binding activity transfected in v-Src transformed mouse NIH3T3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM549118(BDBM50556884 | US11299480, Example 53)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of recombinant wild type tyrosine phosphorylated C-terminal 6His tagged human STAT3 C542S mutant (127 to 711 residues) DNA-binding activit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetSignal transducer and activator of transcription 1/3(Mouse)
University of Hawaii Cancer Center

Curated by ChEMBL
LigandPNGBDBM549118(BDBM50556884 | US11299480, Example 53)
Affinity DataIC50: 1.46E+3nMAssay Description:Inhibition of oligonucleotide [32P]-labelled 5'-AGCITCATTTCCCGTAAATCCCTA probe binding to STAT1/STAT3 heterodimer in mouse NIH3T3 nuclear extract pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM549118(BDBM50556884 | US11299480, Example 53)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of recombinant wild type tyrosine phosphorylated C-terminal 6His tagged human STAT3 C468A mutant (127 to 711 residues) DNA-binding activit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM549118(BDBM50556884 | US11299480, Example 53)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of recombinant wild type tyrosine phosphorylated C-terminal 6His tagged human STAT3 C328A mutant (127 to 711 residues) DNA-binding activit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM549118(BDBM50556884 | US11299480, Example 53)
Affinity DataIC50: 9.70E+3nMAssay Description:Displacement of 5-carboxyfluorescein GpYLPQTV-NH2 probe from C-terminal 6His-tagged recombinant human STAT3 (127 to 711 residues) SH2 domain extracte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM549118(BDBM50556884 | US11299480, Example 53)
Affinity DataIC50: 1.58E+4nMAssay Description:Displacement of 5-carboxyfluorescein GpYLPQTV-NH2 probe from C-terminal 6His-tagged recombinant human STAT3 (127 to 711 residues) SH2 domain extracte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetSignal transducer and activator of transcription 1(Mouse)
University of Hawaii Cancer Center

Curated by ChEMBL
LigandPNGBDBM549118(BDBM50556884 | US11299480, Example 53)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of oligonucleotide [32P]-labelled 5'-AGCITCATTTCCCGTAAATCCCTA probe binding to STAT1 homodimer in mouse NIH3T3 nuclear extract preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM549118(BDBM50556884 | US11299480, Example 53)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant wild type tyrosine phosphorylated C-terminal 6His tagged human STAT3 C426A mutant (127 to 711 residues) DNA-binding activit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM549118(BDBM50556884 | US11299480, Example 53)
Affinity DataIC50: 2.79E+4nMAssay Description:Displacement of 5-carboxyfluorescein GpYLPQTV-NH2 probe from C-terminal 6His-tagged recombinant human STAT3 (127 to 711 residues) SH2 domain extracte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details