BDBM549147 2-(((2S,4s,6S)- 6-((4- (3,3- difluoro- pyrrolidin-1- yl)pyrimidin-2- yl) amino) spiro[3.3] heptan-2- yl)oxy) nicotinamide::US11299488, Example 38

SMILES NC(=O)c1cccnc1O[C@H]1C[C@@]2(C[C@@H](C2)Nc2nccc(n2)N2CCC(F)(F)C2)C1

InChI Key InChIKey=QWXKZVGIVLKWEK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 549147   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM549147(2-(((2S,4s,6S)- 6-((4- (3,3- difluoro- pyrrolidin-...)
Affinity DataIC50: 388nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
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Date in BDB:
7/24/2022
Entry Details
US Patent