BDBM549154 2-(((2S,4s,6S)- 6-((4- ((3-hydroxy- 2,2- dimethyl- propyl) amino) pyrimidin-2- yl)amino) spiro[3.3] heptan-2- yl)oxy) nicotinamide::US11299488, Example 45

SMILES CC(C)(CO)CNc1ccnc(N[C@H]2C[C@]3(C2)C[C@@H](C3)Oc2ncccc2C(N)=O)n1

InChI Key InChIKey=VXWKEHQBDPNATO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 549154   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM549154(2-(((2S,4s,6S)- 6-((4- ((3-hydroxy- 2,2- dimethyl-...)
Affinity DataIC50: 678nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2022
Entry Details
US Patent