BDBM549162 2-(((2S,4s,6S)- 6-((4- (3- (dimethyl- carbamoyl) phenyl) pyrimidin-2- yl)amino) spiro[3.3] heptan-2- yl)oxy) nicotinamide::US11299488, Example 53

SMILES CN(C)C(=O)c1cccc(c1)-c1ccnc(N[C@H]2C[C@]3(C2)C[C@@H](C3)Oc2ncccc2C(N)=O)n1

InChI Key InChIKey=VNJWNDLDBDAPAI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 549162   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM549162(2-(((2S,4s,6S)- 6-((4- (3- (dimethyl- carbamoyl) p...)
Affinity DataIC50: 284nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
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Date in BDB:
7/24/2022
Entry Details
US Patent