BDBM550587 4-[(4,4-Difluoro-8′-methyl-1′,5′-dioxo-1′,5′-dihydro-2′H-spiro[cyclohexane-1,3′-imidazo[1,5-a]pyridin]-6′-yl)amino]-N-[2-(dimethylamino)ethyl]thieno[2,3-d]pyrimidine-6-carboxamide::US11311520, Example 81

SMILES CN(C)CCNC(=O)c1cc2c(Nc3cc(C)c4C(=O)NC5(CCC(F)(F)CC5)n4c3=O)ncnc2s1

InChI Key InChIKey=WQSYFADZIMCZFZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 550587   

TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM550587(4-[(4,4-Difluoro-8′-methyl-1′,5′...)
Affinity DataIC50: 5nMAssay Description:MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...More data for this Ligand-Target Pair
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Date in BDB:
8/6/2022
Entry Details
US Patent