BDBM550738 (3S,4S) and (3S,4R)-2-[4-(1- cyanocyclohexyl)phenyl]-3-(2,3-dihydro- 1,4-benzodioxin-6-yl)-1-oxo-1,2,3,4- tetrahydroisoquinoline-4-carboxylic acid::US11311528, Ex. 1-28::US11311528, Ex. 1-36

SMILES OC(=O)[C@@H]1[C@H](N(C(=O)c2ccccc12)c1ccc(cc1)C1(CCCCC1)C#N)c1ccc2OCCOc2c1

InChI Key InChIKey=CMTMOWRHGCDSPR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 550738   

LigandPNGBDBM550738(US11311528, Ex. 1-36 | (3S,4S) and (3S,4R)-2-[4-(1...)
Affinity DataIC50: 669nMAssay Description:The ability of compounds to bind STING is quantified by their ability to compete with tritiated cGAMP ligand for human STING receptor membrane using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

LigandPNGBDBM550738(US11311528, Ex. 1-36 | (3S,4S) and (3S,4R)-2-[4-(1...)
Affinity DataIC50: 803nMAssay Description:The ability of compounds to bind STING is quantified by their ability to compete with tritiated cGAMP ligand for human STING receptor membrane using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent