BDBM552597 (2E)-N-[2-({4-[3'-(3-chloro-2-methoxyanilino)-4'-oxo-1',4',5',7'-tetrahydrospiro[cyclobutane-1,6'-pyrrolo[3,2-c]pyridin]-2'-yl]pyridin-3-yl}oxy)ethyl]-4-(dimethylamino)-N-methylbut-2-enamide::WO2022101184, Example 10

SMILES COc1c(Cl)cccc1Nc1c([nH]c2CC3(CCC3)NC(=O)c12)-c1ccncc1OCCN(C)C(=O)\C=C\CN(C)C

InChI Key InChIKey=YEXNOMHNQYYBFK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 552597   

TargetEpidermal growth factor receptor [669-770,'SVD',771-1210](Human)
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WIPO
LigandPNGBDBM552597(WO2022101184, Example 10 | (2E)-N-[2-({4-[3'-(3-ch...)
Affinity DataIC50: 3.55nMAssay Description: Inhibitory activity of compounds of the present invention against an Epidermal Growth Factor Receptor (EGFR) with an insertion of the amino acids se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022101184