BDBM552925 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((2-(3-(difluoromethyl)bicyclo[1.1.1]pentan-1-yl)-4,4-dimethylcyclohex-1-en-1-yl)methyl)piperazin-1-yl)-N-((4-(((4-fluorotetrahydro-2H-pyran-4-yl)methyl)amino)-3-nitrophenyl)sulfonyl)benzamide::BDBM555321::BDBM595426::US11318134, Example 35

SMILES CC1(C)CCC(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(NCC5(F)CCOCC5)c([N+](=O)[O-])c4)c(Oc4cnc5[nH]ccc5c4)c3)CC2)=C(C23CC(C(F)F)(C2)C3)C1

InChI Key InChIKey=LQGXGCICJLKEBS-UHFFFAOYSA-N

Data  6 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 552925   

TargetApoptosis regulator Bcl-2(Human)
Recurium Ip Holding

US Patent
LigandChemical structure of BindingDB Monomer ID 552925BDBM552925(US11318134, Example 35 | BDBM595426 | 2-((1H-pyrro...)
Affinity DataKd: <10nMAssay Description:Table 1: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan platform: T7 phage strains displaying BCL2 proteins were grown i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Recurium Ip Holding

US Patent
LigandChemical structure of BindingDB Monomer ID 552925BDBM552925(US11318134, Example 35 | BDBM595426 | 2-((1H-pyrro...)
Affinity DataKd: <10nMAssay Description:Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan platform: T7 phage strains displaying BCL2 proteins were grown in paralle...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2023
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Recurium Ip Holding

US Patent
LigandChemical structure of BindingDB Monomer ID 552925BDBM552925(US11318134, Example 35 | BDBM595426 | 2-((1H-pyrro...)
Affinity DataKd: <10nMAssay Description:Table 1: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan platform: T7 phage strains displaying BCL2 proteins were grown i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
US Patent

TargetBcl-2-like protein 1(Human)
Recurium Ip Holdings

US Patent
LigandChemical structure of BindingDB Monomer ID 552925BDBM552925(US11318134, Example 35 | BDBM595426 | 2-((1H-pyrro...)
Affinity DataKd: >100nMAssay Description:Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan platform: T7 phage strains displaying BCL2 proteins were grown in paralle...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2023
Entry Details
US Patent

TargetBcl2-associated agonist of cell death(Human)
Recurium Ip Holding

US Patent
LigandChemical structure of BindingDB Monomer ID 552925BDBM552925(US11318134, Example 35 | BDBM595426 | 2-((1H-pyrro...)
Affinity DataKd: >100nMAssay Description:Table 1: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan platform: T7 phage strains displaying BCL2 proteins were grown i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
US Patent

TargetBcl-2-like protein 1(Human)
Recurium Ip Holdings

US Patent
LigandChemical structure of BindingDB Monomer ID 552925BDBM552925(US11318134, Example 35 | BDBM595426 | 2-((1H-pyrro...)
Affinity DataKd: >100nMAssay Description:Table 1: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan platform: T7 phage strains displaying BCL2 proteins were grown i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
US Patent