BDBM554447 US11332473, Compound 1.322

SMILES CC(C)n1c(=O)c2cnc(Nc3ccc4c(c3)CNCC4)nc2n1-c1nc(C(C)(C)C#N)ccc1F

InChI Key InChIKey=MLXOCAFBLQQZKS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 554447   

TargetWee1-like protein kinase(Human)
Nuvation Bio

US Patent
LigandChemical structure of BindingDB Monomer ID 554447BDBM554447(US11332473, Compound 1.322)
Affinity DataIC50: 7nMAssay Description:WEE1: IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen Terbium Labeled TR-FRET assay. Kinase assays were performed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 554447BDBM554447(US11332473, Compound 1.322)
Affinity DataIC50: 7.49E+3nMAssay Description:PKMYT1: Inhibition of PKMYT1 kinase activity by test compounds was measured by the HotSpot Kinase Assay at Reaction Biology Corporation (Malvern, Pa....More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details
US Patent