BDBM555324 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((2-(3-isopropylbicyclo [1.1.1]pentan-1l-yl)-4,4-dimethylcyclohex-1-en-1-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide::US11344546, Example 39::US11590126, Example 39

SMILES CC(C)C12CC(C3=C(CN4CCN(c5ccc(C(=O)NS(=O)(=O)c6ccc(NCC7CCOCC7)c([N+](=O)[O-])c6)c(Oc6cnc7[nH]ccc7c6)c5)CC4)CCC(C)(C)C3)(C1)C2

InChI Key InChIKey=STGFWSHUQRPCKJ-UHFFFAOYSA-N

Data  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 555324   

TargetApoptosis regulator Bcl-2(Human)
Recurium Ip Holdings

US Patent
LigandChemical structure of BindingDB Monomer ID 555324BDBM555324(US11344546, Example 39 | 2-((1H-pyrrolo[2,3-b]pyri...)
Affinity DataKd:  55nMAssay Description:Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan platform: T7 phage strains displaying BCL2 proteins were grown in paralle...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2023
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Recurium Ip Holdings

US Patent
LigandChemical structure of BindingDB Monomer ID 555324BDBM555324(US11344546, Example 39 | 2-((1H-pyrrolo[2,3-b]pyri...)
Affinity DataKd:  55nMAssay Description:Table 1: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan platform: T7 phage strains displaying BCL2 proteins were grown i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
US Patent

TargetBcl-2-like protein 1(Human)
Recurium Ip Holdings

US Patent
LigandChemical structure of BindingDB Monomer ID 555324BDBM555324(US11344546, Example 39 | 2-((1H-pyrrolo[2,3-b]pyri...)
Affinity DataKd: >100nMAssay Description:Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan platform: T7 phage strains displaying BCL2 proteins were grown in paralle...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2023
Entry Details
US Patent

TargetBcl2-associated agonist of cell death(Human)
Recurium Ip Holding

US Patent
LigandChemical structure of BindingDB Monomer ID 555324BDBM555324(US11344546, Example 39 | 2-((1H-pyrrolo[2,3-b]pyri...)
Affinity DataKd: >100nMAssay Description:Table 1: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan platform: T7 phage strains displaying BCL2 proteins were grown i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
US Patent