BDBM555465 US11344549, Example 141::US11344549, Example 146

SMILES NC(=O)c1cnc(Nc2cnn(CCO)c2)nc1NCc1c(F)cccc1F

InChI Key InChIKey=YJSFYJMKVAVFQE-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 555465   

TargetTyrosine-protein kinase JAK3(Human)
Beijing Scitech Mq Pharmaceuticals

US Patent
LigandPNGBDBM555465(US11344549, Example 146 | US11344549, Example 141)
Affinity DataIC50: 0.130nMAssay Description:JAK3 (the final concentration was 0.36 nM); ATP (the final concentration was 10 μM); ULight-labeled JAK-1 (Tyr1023) Peptide (the final concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Beijing Scitech Mq Pharmaceuticals

US Patent
LigandPNGBDBM555465(US11344549, Example 146 | US11344549, Example 141)
Affinity DataIC50: 0.190nMAssay Description:JAK3 (the final concentration was 0.36 nM); ATP (the final concentration was 10 μM); ULight-labeled JAK-1 (Tyr1023) Peptide (the final concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Beijing Scitech Mq Pharmaceuticals

US Patent
LigandPNGBDBM555465(US11344549, Example 146 | US11344549, Example 141)
Affinity DataIC50: 0.430nMAssay Description:JAK2 (the final concentration was 0.25 nM); ATP (the final concentration was 5 μM); ULight-labeled JAK-1 (Tyr1023) Peptide (the final concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Beijing Scitech Mq Pharmaceuticals

US Patent
LigandPNGBDBM555465(US11344549, Example 146 | US11344549, Example 141)
Affinity DataIC50: 0.5nMAssay Description:JAK2 (the final concentration was 0.25 nM); ATP (the final concentration was 5 μM); ULight-labeled JAK-1 (Tyr1023) Peptide (the final concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Beijing Scitech Mq Pharmaceuticals

US Patent
LigandPNGBDBM555465(US11344549, Example 146 | US11344549, Example 141)
Affinity DataIC50: 4.32nMAssay Description:JAK1 (the final concentration was 10 nM); ATP (the final concentration was 10 μM); ULight-labeled JAK-1 (Tyr1023) Peptide (the final concentrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Beijing Scitech Mq Pharmaceuticals

US Patent
LigandPNGBDBM555465(US11344549, Example 146 | US11344549, Example 141)
Affinity DataIC50: 7.69nMAssay Description:JAK1 (the final concentration was 10 nM); ATP (the final concentration was 10 μM); ULight-labeled JAK-1 (Tyr1023) Peptide (the final concentrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
US Patent