BDBM555481 US11344549, Example 157

SMILES COc1cccc(F)c1CNc1nc(Nc2cnn(c2)C2CCOCC2)ncc1C(N)=O

InChI Key InChIKey=RVUUYYGYSXNUNC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 555481   

TargetTyrosine-protein kinase JAK2(Human)
Beijing Scitech Mq Pharmaceuticals

US Patent
LigandPNGBDBM555481(US11344549, Example 157)
Affinity DataIC50: 0.140nMAssay Description:JAK2 (the final concentration was 0.25 nM); ATP (the final concentration was 5 μM); ULight-labeled JAK-1 (Tyr1023) Peptide (the final concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Beijing Scitech Mq Pharmaceuticals

US Patent
LigandPNGBDBM555481(US11344549, Example 157)
Affinity DataIC50: 0.410nMAssay Description:JAK3 (the final concentration was 0.36 nM); ATP (the final concentration was 10 μM); ULight-labeled JAK-1 (Tyr1023) Peptide (the final concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Beijing Scitech Mq Pharmaceuticals

US Patent
LigandPNGBDBM555481(US11344549, Example 157)
Affinity DataIC50: 1.86nMAssay Description:JAK1 (the final concentration was 10 nM); ATP (the final concentration was 10 μM); ULight-labeled JAK-1 (Tyr1023) Peptide (the final concentrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
US Patent