BDBM556334 3-(4-((6-(5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)pyrimidin-2-ylamino)pyridin-3-yloxy)methyl)piperidin-1-yl)propan-1-ol (Compound 72)::US11351170, Example 11

SMILES CC1(C)CCc2nc3c(F)cc(cc3n12)-c1nc(Nc2ccc(OCC3CCN(CCCO)CC3)cn2)ncc1F

InChI Key InChIKey=NXMIQKJGFTVADM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 556334   

TargetCyclin-dependent kinase 4(Human)
Beijing Xuanyi Pharmasciences

US Patent
LigandPNGBDBM556334(US11351170, Example 11 | 3-(4-((6-(5-fluoro-4-(5-f...)
Affinity DataIC50: 0.110nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
US Patent

TargetCyclin-dependent kinase 6(Human)
Beijing Xuanyi Pharmasciences

US Patent
LigandPNGBDBM556334(US11351170, Example 11 | 3-(4-((6-(5-fluoro-4-(5-f...)
Affinity DataIC50: 1.02nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were respectively dissolved in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
US Patent

TargetCyclin-dependent kinase 2(Human)
Beijing Xuanyi Pharmasciences

US Patent
LigandPNGBDBM556334(US11351170, Example 11 | 3-(4-((6-(5-fluoro-4-(5-f...)
Affinity DataIC50: 44.9nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
US Patent

TargetCyclin-dependent kinase 5(Human)
Beijing Xuanyi Pharmasciences

US Patent
LigandPNGBDBM556334(US11351170, Example 11 | 3-(4-((6-(5-fluoro-4-(5-f...)
Affinity DataIC50: 128nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
US Patent