BDBM557403 6-[4-amino-1- (3-hydroxy- 3-methyl- cyclopentyl) pyrazolo[3,4- d]pyrimidin- 3-yl]-N- methyl-1H- indole-2- carboxamide::US11352361, Example 52::US11680068, Example 52

SMILES CNC(=O)c1cc2ccc(cc2[nH]1)-c1nn(C2CCC(C)(O)C2)c2ncnc(N)c12

InChI Key InChIKey=BEPLRYGWKGEZCF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 557403   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM557403(US11352361, Example 52 | 6-[4-amino-1- (3-hydroxy-...)
Affinity DataIC50: 74.4nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM557403(US11352361, Example 52 | 6-[4-amino-1- (3-hydroxy-...)
Affinity DataIC50: 74.4nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2022
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM557403(US11352361, Example 52 | 6-[4-amino-1- (3-hydroxy-...)
Affinity DataIC50: 1.30E+4nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2023
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM557403(US11352361, Example 52 | 6-[4-amino-1- (3-hydroxy-...)
Affinity DataIC50: 1.30E+4nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2022
Entry Details
US Patent