BDBM557404 6-(4-amino- 1-isopropyl- pyrazolo[3,4-d] pyrimidin- 3-yl)-N,3- dimethyl-1H- indole-2- carboxamide::US11352361, Example 53::US11680068, Example 53

SMILES CNC(=O)c1[nH]c2cc(ccc2c1C)-c1nn(C(C)C)c2ncnc(N)c12

InChI Key InChIKey=KDJWXPGGGCQUAI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 557404   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM557404(US11352361, Example 53 | 6-(4-amino- 1-isopropyl- ...)
Affinity DataIC50: 12.1nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM557404(US11352361, Example 53 | 6-(4-amino- 1-isopropyl- ...)
Affinity DataIC50: 12.1nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2022
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM557404(US11352361, Example 53 | 6-(4-amino- 1-isopropyl- ...)
Affinity DataIC50: 456nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2023
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM557404(US11352361, Example 53 | 6-(4-amino- 1-isopropyl- ...)
Affinity DataIC50: 456nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2022
Entry Details
US Patent