BDBM5592 2-arylamino-pyrimidine deriv. 9b::6-(cyclohexylmethoxy)-2-N-(4-methoxyphenyl)-5-nitrosopyrimidine-2,4-diamine

SMILES COc1ccc(Nc2nc(N)c(N=O)c(OCC3CCCCC3)n2)cc1

InChI Key InChIKey=WWJLGEMPECUYJI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 5592   

TargetCyclin-A2 [171-432]/Cyclin-dependent kinase 2(Human)
University of Newcastle

LigandPNGBDBM5592(6-(cyclohexylmethoxy)-2-N-(4-methoxyphenyl)-5-nitr...)
Affinity DataIC50: 220nMpH: 7.5 T: 2°CAssay Description:The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
University of Newcastle

LigandPNGBDBM5592(6-(cyclohexylmethoxy)-2-N-(4-methoxyphenyl)-5-nitr...)
Affinity DataIC50: 230nMpH: 7.5 T: 2°CAssay Description:The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2005
Entry Details Article
PubMed