BDBM562352 (rac)-13-Fluoro-1-(3-((6-fluoronaphthalen-1-yl)oxy)propyl)-8,11,12-trimethyl-5,6,9,11-tetrahydro-4H,8H-pyrazolo[3′,4′:4,5][1]thia[2,8]diazacycloundecino[6,7,8-hi]indole-2-carboxylic acid 7,7-dioxide::US11401278, Example 25
SMILES CN1Cc2nn(C)c(C)c2-c2c(F)ccc3c(CCCOc4cccc5cc(F)ccc45)c(C(O)=O)n(CCCS1(=O)=O)c23
InChI Key InChIKey=SFAUIQOMBNEQSP-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 562352
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [173-329]/Phorbol-Phorbol-12-myristate-13-acetate-induced protein 1 [26-43](Human)
The Broad Institute
US Patent
The Broad Institute
US Patent
Affinity DataIC50: 1.70nMAssay Description:MCL-1/Noxa BH3 Peptide (MCL-1 Assay): From there, 50 nl were transferred in a dark test plate (Greiner Bio-One, Frickenhausen, Germany). The assay wa...More data for this Ligand-Target Pair
TargetBcl-2-like protein 1/Bcl2-associated agonist of cell death [103-127,M117N](Human)
The Broad Institute
US Patent
The Broad Institute
US Patent
Affinity DataIC50: >2.00E+4nMAssay Description:BCL-XL/Bad BH3 Peptide (BCL-XL Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-XL solution (usually for a...More data for this Ligand-Target Pair
TargetApoptosis regulator Bcl-2/Bcl2-associated agonist of cell death [103-127,M117N](Human)
The Broad Institute
US Patent
The Broad Institute
US Patent
Affinity DataIC50: >2.00E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair