BDBM562786 4-((R)-2-((2S,3R,6S)-2,3-Bis(4-chlorophenyl)-6-(4-cyanobenzyl)-5-oxomorpholino)pentanamido)butanoic acid::US11407721, Example 32::US11407721, Example 33
SMILES CCC[C@@H](N1[C@@H]([C@@H](O[C@@H](Cc2ccc(cc2)C#N)C1=O)c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(=O)NCCCC(O)=O
InChI Key InChIKey=IOBJPQJJXSHZBT-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 562786
Affinity DataIC50: 39.9nMAssay Description:The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...More data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:As the potencies of the HDM2 inhibitors increased, an improved HTRF assay (HTRF2 assay) was developed. All assay conditions remained the same as desc...More data for this Ligand-Target Pair
Affinity DataIC50: 171nMAssay Description:This assay was run using the same conditions as the HTRF1 assay except that 20 uL of GST-hMDM2 was incubated with 1.0 ul of diluted compound.More data for this Ligand-Target Pair
Affinity DataIC50: 199nMAssay Description:As the potencies of the HDM2 inhibitors increased, an improved HTRF assay (HTRF2 assay) was developed. All assay conditions remained the same as desc...More data for this Ligand-Target Pair