BDBM562809 (R)-2-((2S,3R,6S)-2,3-Bis(4-chlorophenyl)-5-oxo-6-(4-((trifluoromethyl)sulfonyl)benzyl)morpholino)pentanoic acid::US11407721, Example 56

SMILES CCC[C@@H](N1[C@@H]([C@@H](O[C@@H](Cc2ccc(cc2)S(=O)(=O)C(F)(F)F)C1=O)c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(O)=O

InChI Key InChIKey=YVJUKVSHQAHNBQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 562809   

TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Human)
Amgen

US Patent
LigandPNGBDBM562809(US11407721, Example 56 | (R)-2-((2S,3R,6S)-2,3-Bis...)
Affinity DataIC50: 453nMAssay Description:As the potencies of the HDM2 inhibitors increased, an improved HTRF assay (HTRF2 assay) was developed. All assay conditions remained the same as desc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
US Patent