BDBM565132 BDBM565147::US11414404, Ex. # 9::US11634409, Example 24

SMILES CCCS(=O)(=O)Nc1ccc(F)c(Nc2ccc3ncn(C)c(=O)c3c2C)c1Cl

InChI Key InChIKey=TVRGSVQGWXYCGL-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 565132   

TargetSerine/threonine-protein kinase B-raf [V600K](Human)
Array Biopharma

US Patent
LigandPNGBDBM565132(US11414404, Ex. # 9 | BDBM565147 | US11634409, Exa...)
Affinity DataIC50: 6.5nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Array Biopharma

US Patent
LigandPNGBDBM565132(US11414404, Ex. # 9 | BDBM565147 | US11634409, Exa...)
Affinity DataIC50: 9.05nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Enliven Therapeutics

Curated by ChEMBL
LigandPNGBDBM565132(US11414404, Ex. # 9 | BDBM565147 | US11634409, Exa...)
Affinity DataIC50: 15nMAssay Description:Inhibition of 6-His tagged BRAF V600E mutant (445 to 723 residues) (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Array Biopharma

US Patent
LigandPNGBDBM565132(US11414404, Ex. # 9 | BDBM565147 | US11634409, Exa...)
Affinity DataIC50: 19.7nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Enliven Therapeutics

Curated by ChEMBL
LigandPNGBDBM565132(US11414404, Ex. # 9 | BDBM565147 | US11634409, Exa...)
Affinity DataIC50: 36nMAssay Description:Inhibition of BRAF V600E mutant in human A-375 cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed