BDBM565154 N-(2-chloro-3-((3- cyclopropyl-5-methyl-4- oxo-3,4-dihydroquinazolin- 6-yl)amino)-4- fluorophenyl)propane-1- sulfonamide trifluoroacetate::US11414404, Ex. # 31::US11634409, Example 31

SMILES CCCS(=O)(=O)Nc1ccc(F)c(Nc2ccc3ncn(C4CC4)c(=O)c3c2C)c1Cl

InChI Key InChIKey=HVTRWUIKDRPERZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 565154   

TargetSerine/threonine-protein kinase B-raf(Human)
Enliven Therapeutics

Curated by ChEMBL
LigandPNGBDBM565154(US11414404, Ex. # 31 | N-(2-chloro-3-((3- cyclopro...)
Affinity DataIC50: 12nMAssay Description:Inhibition of 6-His tagged BRAF V600E mutant (445 to 723 residues) (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Array Biopharma

US Patent
LigandPNGBDBM565154(US11414404, Ex. # 31 | N-(2-chloro-3-((3- cyclopro...)
Affinity DataIC50: 25.1nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Enliven Therapeutics

Curated by ChEMBL
LigandPNGBDBM565154(US11414404, Ex. # 31 | N-(2-chloro-3-((3- cyclopro...)
Affinity DataIC50: 62nMAssay Description:Inhibition of BRAF V600E mutant in human A-375 cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed