BDBM565159 N-(2-chloro-4-fluoro-3-((3- isopropyl-5-methyl-4-oxo- 3,4-dihydroquinazolin-6- yl)amino)phenyl)propane- 1-sulfonamide trifluoroacetate::US11414404, Ex. # 36::US11634409, Example 36

SMILES CCCS(=O)(=O)Nc1ccc(F)c(Nc2ccc3ncn(C(C)C)c(=O)c3c2C)c1Cl

InChI Key InChIKey=LOLGHIYCCWBOTE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 565159   

TargetSerine/threonine-protein kinase B-raf(Human)
Enliven Therapeutics

Curated by ChEMBL
LigandPNGBDBM565159(US11414404, Ex. # 36 | N-(2-chloro-4-fluoro-3-((3-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of 6-His tagged BRAF V600E mutant (445 to 723 residues) (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Array Biopharma

US Patent
LigandPNGBDBM565159(US11414404, Ex. # 36 | N-(2-chloro-4-fluoro-3-((3-...)
Affinity DataIC50: 26.4nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Enliven Therapeutics

Curated by ChEMBL
LigandPNGBDBM565159(US11414404, Ex. # 36 | N-(2-chloro-4-fluoro-3-((3-...)
Affinity DataIC50: 187nMAssay Description:Inhibition of BRAF V600E mutant in human A-375 cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed