BDBM565160 N-(2-chloro-3-((3-ethyl-5- methyl-4-oxo-3,4- dihydroquinazolin-6- yl)amino)-4- fluorophenyl)propane-1- sulfonamide trifluoroacetate::US11414404, Ex. # 37::US11634409, Example 37

SMILES CCCS(=O)(=O)Nc1ccc(F)c(Nc2ccc3ncn(CC)c(=O)c3c2C)c1Cl

InChI Key InChIKey=VWWHDMOYTAAZBX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 565160   

TargetSerine/threonine-protein kinase B-raf(Human)
Enliven Therapeutics

Curated by ChEMBL
LigandPNGBDBM565160(US11414404, Ex. # 37 | N-(2-chloro-3-((3-ethyl-5- ...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of 6-His tagged BRAF V600E mutant (445 to 723 residues) (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Array Biopharma

US Patent
LigandPNGBDBM565160(US11414404, Ex. # 37 | N-(2-chloro-3-((3-ethyl-5- ...)
Affinity DataIC50: 5.5nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Enliven Therapeutics

Curated by ChEMBL
LigandPNGBDBM565160(US11414404, Ex. # 37 | N-(2-chloro-3-((3-ethyl-5- ...)
Affinity DataIC50: 27nMAssay Description:Inhibition of BRAF V600E mutant in human A-375 cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed