BDBM565173 N-(2-chloro-3-((3,5- dimethyl-4-oxo-3,4- dihydroquinazolin-6- yl)amino)-4- fluorophenyl)-1- cyclopropylmethane- sulfonamide::US11414404, Ex. # 50::US11634409, Example 50

SMILES Cc1c(Nc2c(F)ccc(NS(=O)(=O)CC3CC3)c2Cl)ccc2ncn(C)c(=O)c12

InChI Key InChIKey=MJXIXQYIMFYSNU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 565173   

TargetSerine/threonine-protein kinase B-raf(Human)
Enliven Therapeutics

Curated by ChEMBL
LigandPNGBDBM565173(US11414404, Ex. # 50 | N-(2-chloro-3-((3,5- dimeth...)
Affinity DataIC50: 46nMAssay Description:Inhibition of 6-His tagged BRAF V600E mutant (445 to 723 residues) (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Array Biopharma

US Patent
LigandPNGBDBM565173(US11414404, Ex. # 50 | N-(2-chloro-3-((3,5- dimeth...)
Affinity DataIC50: 66.1nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Enliven Therapeutics

Curated by ChEMBL
LigandPNGBDBM565173(US11414404, Ex. # 50 | N-(2-chloro-3-((3,5- dimeth...)
Affinity DataIC50: 94nMAssay Description:Inhibition of BRAF V600E mutant in human A-375 cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed