BDBM5654 2-amino-5-thio-substituted thiazole 1::[[2-(Acetylamino)-5-thiazolyl]thio]acetic Acid Ethyl Ester::ethyl 2-[(2-acetamido-1,3-thiazol-5-yl)sulfanyl]acetate

SMILES CCOC(=O)CSc1cnc(NC(C)=O)s1

InChI Key InChIKey=GGSRHUNACTWBRD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 5654   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5654(ethyl 2-[(2-acetamido-1,3-thiazol-5-yl)sulfanyl]ac...)
Affinity DataIC50: 170nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5654(ethyl 2-[(2-acetamido-1,3-thiazol-5-yl)sulfanyl]ac...)
Affinity DataIC50: 1.87E+3nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5654(ethyl 2-[(2-acetamido-1,3-thiazol-5-yl)sulfanyl]ac...)
Affinity DataIC50: 2.30E+4nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed