BDBM567153 3-((2S,5R)-2-methyl-5-((5-(oxazol-2-yl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin- 1-yl)-3-oxopropanenitrile::US11420966, Example 28

SMILES C[C@H]1CC[C@H](CN1C(=O)CC#N)Nc1c(cnc2[nH]ccc12)-c1ncco1

InChI Key InChIKey=VDQPIFOHRVYIIF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 567153   

TargetTyrosine-protein kinase JAK2(Human)
Aclaris Therapeutics

US Patent
LigandPNGBDBM567153(3-((2S,5R)-2-methyl-5-((5-(oxazol-2-yl)-1H- pyrrol...)
Affinity DataIC50: 10nMAssay Description:The activity of JAK3 (a.a. 781-1124, ThermoFisher) was quantified by measuring the phosphorylation of SRCtide (FAM-GEEPLYWSFPAKKK-NH2). Kinase reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3 [781-1124](Human)
Aclaris Therapeutics

US Patent
LigandPNGBDBM567153(3-((2S,5R)-2-methyl-5-((5-(oxazol-2-yl)-1H- pyrrol...)
Affinity DataIC50: 10nMAssay Description:The activity of JAK3 (a.a. 781-1124, ThermoFisher) was quantified by measuring the phosphorylation of SRCtide (FAM-GEEPLYWSFPAKKK-NH2). Kinase reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Aclaris Therapeutics

US Patent
LigandPNGBDBM567153(3-((2S,5R)-2-methyl-5-((5-(oxazol-2-yl)-1H- pyrrol...)
Affinity DataIC50: 10nMAssay Description:The activity of JAK3 (a.a. 781-1124, ThermoFisher) was quantified by measuring the phosphorylation of SRCtide (FAM-GEEPLYWSFPAKKK-NH2). Kinase reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Aclaris Therapeutics

US Patent
LigandPNGBDBM567153(3-((2S,5R)-2-methyl-5-((5-(oxazol-2-yl)-1H- pyrrol...)
Affinity DataIC50: 10nMAssay Description:The activity of JAK3 (a.a. 781-1124, ThermoFisher) was quantified by measuring the phosphorylation of SRCtide (FAM-GEEPLYWSFPAKKK-NH2). Kinase reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent