BDBM567154 2-(4-(((1S,3R)-3-hydroxycyclopentyl) amino)-1H-pyrrolo[2,3-b] pyridin-5-yl)oxazole-4-carboxamide::US11420966, Example 29

SMILES NC(=O)c1coc(n1)-c1cnc2[nH]ccc2c1N[C@H]1CC[C@@H](O)C1

InChI Key InChIKey=WSYVCJVVFLWEDO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 567154   

TargetTyrosine-protein kinase JAK3 [781-1124](Human)
Aclaris Therapeutics

US Patent
LigandPNGBDBM567154(2-(4-(((1S,3R)-3-hydroxycyclopentyl) amino)-1H-pyr...)
Affinity DataIC50: 10nMAssay Description:The activity of JAK3 (a.a. 781-1124, ThermoFisher) was quantified by measuring the phosphorylation of SRCtide (FAM-GEEPLYWSFPAKKK-NH2). Kinase reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Aclaris Therapeutics

US Patent
LigandPNGBDBM567154(2-(4-(((1S,3R)-3-hydroxycyclopentyl) amino)-1H-pyr...)
Affinity DataIC50: 55nMAssay Description:The activity of JAK3 (a.a. 781-1124, ThermoFisher) was quantified by measuring the phosphorylation of SRCtide (FAM-GEEPLYWSFPAKKK-NH2). Kinase reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Aclaris Therapeutics

US Patent
LigandPNGBDBM567154(2-(4-(((1S,3R)-3-hydroxycyclopentyl) amino)-1H-pyr...)
Affinity DataIC50: 55nMAssay Description:The activity of JAK3 (a.a. 781-1124, ThermoFisher) was quantified by measuring the phosphorylation of SRCtide (FAM-GEEPLYWSFPAKKK-NH2). Kinase reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Aclaris Therapeutics

US Patent
LigandPNGBDBM567154(2-(4-(((1S,3R)-3-hydroxycyclopentyl) amino)-1H-pyr...)
Affinity DataIC50: 550nMAssay Description:The activity of JAK3 (a.a. 781-1124, ThermoFisher) was quantified by measuring the phosphorylation of SRCtide (FAM-GEEPLYWSFPAKKK-NH2). Kinase reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent