BDBM567166 (R)-3-(3-((5-(isothiazol-3-yl)-1H- pyrrolo[2,3-b]pyridin-4-yl)amino)piperidin- 1-yl)-3-oxopropanenitrile::US11420966, Example 41

SMILES O=C(CC#N)N1CCCC(C1)Nc1c(cnc2[nH]ccc12)-c1ccsn1

InChI Key InChIKey=SXQJHEQEYPDLIP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 567166   

TargetTyrosine-protein kinase JAK2(Human)
Aclaris Therapeutics

US Patent
LigandPNGBDBM567166((R)-3-(3-((5-(isothiazol-3-yl)-1H- pyrrolo[2,3-b]p...)
Affinity DataIC50: 10nMAssay Description:The activity of JAK3 (a.a. 781-1124, ThermoFisher) was quantified by measuring the phosphorylation of SRCtide (FAM-GEEPLYWSFPAKKK-NH2). Kinase reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3 [781-1124](Human)
Aclaris Therapeutics

US Patent
LigandPNGBDBM567166((R)-3-(3-((5-(isothiazol-3-yl)-1H- pyrrolo[2,3-b]p...)
Affinity DataIC50: 10nMAssay Description:The activity of JAK3 (a.a. 781-1124, ThermoFisher) was quantified by measuring the phosphorylation of SRCtide (FAM-GEEPLYWSFPAKKK-NH2). Kinase reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Aclaris Therapeutics

US Patent
LigandPNGBDBM567166((R)-3-(3-((5-(isothiazol-3-yl)-1H- pyrrolo[2,3-b]p...)
Affinity DataIC50: 10nMAssay Description:The activity of JAK3 (a.a. 781-1124, ThermoFisher) was quantified by measuring the phosphorylation of SRCtide (FAM-GEEPLYWSFPAKKK-NH2). Kinase reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Aclaris Therapeutics

US Patent
LigandPNGBDBM567166((R)-3-(3-((5-(isothiazol-3-yl)-1H- pyrrolo[2,3-b]p...)
Affinity DataIC50: 10nMAssay Description:The activity of JAK3 (a.a. 781-1124, ThermoFisher) was quantified by measuring the phosphorylation of SRCtide (FAM-GEEPLYWSFPAKKK-NH2). Kinase reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent