BDBM567689 US11420968, Example F55

SMILES [O-][N+](=O)c1cc(ccc1NCC1CCOCC1)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCC2(CC(C2)N2CCC[C@H]2c2ccccc2Cl)CC1

InChI Key InChIKey=ORZUFNOOMDCXOS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 567689   

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandPNGBDBM567689(US11420968, Example F55)
Affinity DataIC50: 0.310nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandPNGBDBM567689(US11420968, Example F55)
Affinity DataIC50: 0.310nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandPNGBDBM567689(US11420968, Example F55)
Affinity DataIC50: 0.360nMAssay Description:Inhibition of Bcl-2 (unknown origin) using (Ac-GQVGRQLAIIGDK (FITC) INR-amide) as substrate preincubated for 30 mins followed by substrate addition a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandPNGBDBM567689(US11420968, Example F55)
Affinity DataIC50: 24nMAssay Description:Inhibition of Bcl-2 G101V mutant (unknown origin) using (Ac-GQVGRQLAIIGDK (FITC) INR-amide) as substrate preincubated for 30 mins followed by substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetBcl-2-like protein 1(Human)
BeiGene(Beiing) Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM567689(US11420968, Example F55)
Affinity DataIC50: 266nMAssay Description:Inhibition of Bcl-Xl (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetBcl-2-like protein 1(Human)
BeiGene(Beiing) Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM567689(US11420968, Example F55)
Affinity DataIC50: 320nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent