BDBM568343 US11420973, Example 221

SMILES CCCN1CCC(N(C(=O)c2ccc3[nH]c(-c4cn(C)c(=O)c(Cl)c4C)c(C(C)C)c3c2)C2CC2)CC1

InChI Key InChIKey=WKGDYNVKEJJWCZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 568343   

TargetToll-like receptor 8(Human)
Bristol Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 568343BDBM568343(US11420973, Example 221)
Affinity DataIC50: 0.700nMAssay Description:HEK-Blue -cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Bristol Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 568343BDBM568343(US11420973, Example 221)
Affinity DataIC50: 5.20nMAssay Description:HEK-Blue -cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetToll-like receptor 9(Human)
Bristol Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 568343BDBM568343(US11420973, Example 221)
Affinity DataIC50: 2.94E+3nMAssay Description:HEK-Blue -cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent