BDBM568353 US11420975, Compound A-10-5

SMILES CC1(COC1)C(=O)NC12CCC(CC1)(C2)c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12

InChI Key InChIKey=AABYXJCZMWYZBG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 568353   

TargetTyrosine-protein kinase BTK [C481S](Human)
Transthera Sciences (Nanjing)

US Patent
LigandPNGBDBM568353(US11420975, Compound A-10-5 | US12291534, Compound...)
Affinity DataIC50: 0.100nMAssay Description:The substrate solution was prepared by adding the substrate poly(Glu, Tyr) sodium salt (Sigma Aldrich, St. Louis, Mo.) to the substrate reaction buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Transthera Sciences (Nanjing)

US Patent
LigandPNGBDBM568353(US11420975, Compound A-10-5 | US12291534, Compound...)
Affinity DataIC50: 0.100nMAssay Description:The substrate solution was prepared by adding the substrate poly(Glu, Tyr) sodium salt (Sigma Aldrich, St. Louis, MO) to the substrate reaction buffe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2025
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Transthera Sciences (Nanjing)

US Patent
LigandPNGBDBM568353(US11420975, Compound A-10-5 | US12291534, Compound...)
Affinity DataIC50: 5.5nMAssay Description:The substrate solution was prepared by adding the substrate poly(Glu, Tyr) sodium salt (Sigma Aldrich, St. Louis, Mo.) to the substrate reaction buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Transthera Sciences (Nanjing)

US Patent
LigandPNGBDBM568353(US11420975, Compound A-10-5 | US12291534, Compound...)
Affinity DataIC50: 5.5nMAssay Description:The substrate solution was prepared by adding the substrate poly(Glu, Tyr) sodium salt (Sigma Aldrich, St. Louis, MO) to the substrate reaction buffe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2025
Entry Details
US Patent