BDBM568864 US11427558, Example 11

SMILES O=C(Nc1ccc2[nH]nc(-c3ccoc3)c2c1)c1ccc(cc1)C#N

InChI Key InChIKey=PGXIWSRADSNICD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 568864   

LigandPNGBDBM568864(US11427558, Example 11)
Affinity DataIC50: 41nMAssay Description:Inhibition of LRRK2 G2019S mutant (unknown origin) using LRRKtide as substrate pre-incubated for 15 min and measured after 1 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM568864(US11427558, Example 11)
Affinity DataIC50: 100nMAssay Description:The assay was carried out under the following protocol conditions: 1 mM compound in DMSO was serially diluted 1:3, 11 points in DMSO with a Biomek FX...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2022
Entry Details
US Patent

LigandPNGBDBM568864(US11427558, Example 11)
Affinity DataIC50: 550nMAssay Description:The assay was carried out under the following protocol conditions: 1 mM compound in DMSO was serially diluted 1:3, 11 points in DMSO with a Biomek FX...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2022
Entry Details
US Patent