BDBM569889 (+/−)-5-{4-[4-{5-(hydroxymethyl)-5-methyl-5,6-dihydro-4H-1,3-oxazin-2-yl]amino}-2-(trifluoromethyl)phenoxy]-1H-pyrrolo[2,3-b]pyridin-3-yl}-2-[(propan-2-yl)oxy]benzonitrile::US11427578, Example 62

SMILES CC(C)Oc1ccc(cc1C#N)-c1c[nH]c2nccc(Oc3ccc(NC4=NCC(C)(CO)CO4)cc3C(F)(F)F)c12

InChI Key InChIKey=LWEZETWINKLTAA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 569889   

TargetSerine/threonine-protein kinase TBK1(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM569889((+/−)-5-{4-[4-{5-(hydroxymethyl)-5-methyl-5,...)
Affinity DataIC50: 1.49E+4nMAssay Description:For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtiter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2022
Entry Details
US Patent