BDBM569916 (+/−)-5-[4-(2,6-difluoro-4-{[5-(hydroxymethyl)-5-methyl-5,6-dihydro-4H-1,3-oxazin-2-yl]amino}phenoxy)-1H-pyrrolo[2,3-b]pyridin-3-yl]-2-(2,2,2-trifluoroethoxy)benzonitrile::US11427578, Example 89

SMILES CC1(CO)COC(Nc2cc(F)c(Oc3ccnc4[nH]cc(-c5ccc(OCC(F)(F)F)c(c5)C#N)c34)c(F)c2)=NC1

InChI Key InChIKey=WSNNOTLCSPSVMU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 569916   

TargetSerine/threonine-protein kinase TBK1(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM569916((+/−)-5-[4-(2,6-difluoro-4-{[5-(hydroxymethy...)
Affinity DataIC50: 1.90E+4nMAssay Description:For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtiter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2022
Entry Details
US Patent