BDBM569961 5-(4-{2,6-difluoro-4-[(5-oxa-7-azaspiro[2.5]oct-6-en-6-yl)amino]phenoxy}-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-[(propan-2-yl)oxy]benzonitrile::US11427578, Example 134

SMILES CC(C)Oc1ccc(cc1C#N)-c1c[nH]c2nccc(Oc3c(F)cc(NC4=NCC5(CC5)CO4)cc3F)c12

InChI Key InChIKey=XXEMVDXNIHRGPG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 569961   

TargetSerine/threonine-protein kinase TBK1(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM569961(5-(4-{2,6-difluoro-4-[(5-oxa-7-azaspiro[2.5]oct-6-...)
Affinity DataIC50: 2.00E+3nMAssay Description:For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtiter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2022
Entry Details
US Patent

TargetSerine/threonine-protein kinase TBK1(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM569961(5-(4-{2,6-difluoro-4-[(5-oxa-7-azaspiro[2.5]oct-6-...)
Affinity DataIC50: 2.00E+4nMAssay Description:For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtiter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2022
Entry Details
US Patent