BDBM570511 Preparation of N2-((1R,3s,5S)-9-(ethylsulfonyl)-9-azabicyclo[3.3.1]nonan-3-yl)-5-fluoro-N2-methyl-N4-(5-methyl-1H-pyrazol-3-yl)-6-((((S)-tetrahydrofuran-3-yl)oxy)methyl)pyrimidine-2,4-diamine (Ex. 42) and N2-((1R,3s,5S)-9-(ethylsulfonyl)-9-azabicyclo[3.3.1]nonan-3-yl)-5-fluoro-N2-methyl-N4-(5-methyl-1H-pyrazol-3-yl)-6-((((R)-tetrahydrofuran-3-yl)oxy)methyl)pyrimidine-2,4-diamine (Ex. 43)::US11439641, Example 43

SMILES CCS(=O)(=O)N1[C@H]2CCC[C@@H]1C[C@H](C2)N(C)c1nc(CO[C@@H]2CCOC2)c(F)c(Nc2cc(C)[nH]n2)n1

InChI Key

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 570511   

TargetTyrosine-protein kinase JAK2(Human)
Theravance Biopharma R&D Ip

US Patent
LigandPNGBDBM570511(Preparation of N2-((1R,3s,5S)-9-(ethylsulfonyl)-9-...)
Affinity DataKi: <0.100nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Theravance Biopharma R&D Ip

US Patent
LigandPNGBDBM570511(Preparation of N2-((1R,3s,5S)-9-(ethylsulfonyl)-9-...)
Affinity DataKi: <0.100nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetTyrosine-protein kinase JAK3(Human)
Theravance Biopharma R&D Ip

US Patent
LigandPNGBDBM570511(Preparation of N2-((1R,3s,5S)-9-(ethylsulfonyl)-9-...)
Affinity DataKi:  0.550nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetTyrosine-protein kinase JAK1(Human)
Theravance Biopharma R&D Ip

US Patent
LigandPNGBDBM570511(Preparation of N2-((1R,3s,5S)-9-(ethylsulfonyl)-9-...)
Affinity DataKi:  0.550nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent